ITDETECT: A METHOD TO DETECT INTERNAL TANDEM DUPLICATION OF FMS-LIKE TYROSINE KINASE (FLT3) FROM NEXT-GENERATION SEQUENCING DATA WITH HIGH SENSITIVITY AND CLINICAL APPLICATION

Abstract Internal tandem duplication (ITD) of the FMS-like tyrosine kinase (FLT3) gene is associated with poor clinical outcomes in patients with acute myeloid leukemia.Although recent methods for detecting FLT3-ITD from next-generation sequencing (NGS) data have replaced traditional ITD detection approaches such as conventional PCR or fragment ana

Abstract We study half-BPS surface operators in supersymmetric gauge theories in four and five dimensions following two different approaches.In the first approach we analyze the chiral ring equations for certain quiver theories in two and three dimensions, coupled respectively to four- and five-dimensional gauge theories.The chiral ring equations,

During a decision making process, the body changes.These somatic changes have been Miscellaneous related to specific cognitive events and also have been postulated to assist decision making indexing possible outcomes of different options.We used chess to analyze heart rate (HR) modulations on specific cognitive events.In a chess game, players have

SARA (Saturates, Aromatics, Resins, Asphaltenes) fractionation is a common simplification technique used for decades in petrochemical analysis.A large number of studies are dealing with the Miscellaneous different fractions, but overall, the saturate fraction is strongly neglected.Of the very few available studies on the saturates fraction, almost